Transitions in frailty phenotype states and components over 8 years: Evidence from The Irish Longitudinal Study on Ageing

Fried's frailty phenotype (FP) is defined by exhaustion (EX), unexplained weight loss (WL), weakness (WK), slowness (SL) and low physical activity (LA). Three or more components define the frail state, one two prefrail. We described longitudinal transitions of FP states in The Irish Longitudinal Study on Ageing (TILDA). included participants aged ?50 years with information at TILDA wave 1 (2010), who were followed-up over four waves (2012, 2014, 2016, 2018). Next-wave transition probabilities estimated multi-state Markov models. 5683 (2612 men 3071 women; mean age 63.1 years). Probabilities from non-frail to prefrail, 27% 2%, respectively. Prefrail had a 32% probability reversal non-frail, 10% risk progression frail. Frail an 18% prefrail 31% death. transitioning not having component were: 17% for LA, 11% SL, 9% EX, 7% WL 6% WK. dying WL, 15% WK, 14% 13% LA. recovering next 59% 58% 40% 35% LA 23% SL. are characterized dynamic transitions. Opportunities exist reducing adverse